Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain

Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson’s disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA) neurotransmission. Previous studies of...

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Bibliographic Details
Main Authors: Tatiana V. Tarasova, Olga A. Lytkina, Valeria V. Goloborshcheva, Larisa N. Skuratovskaya, Alexandr I. Antohin, Ruslan K. Ovchinnikov, Michail S. Kukharsky
Format: Article
Language:English
Published: PeerJ Inc. 2018-05-01
Series:PeerJ
Subjects:
Synuclein
Knockout mice
Parkinson’s disease
Dopaminergic neurons
Online Access:https://peerj.com/articles/4779.pdf

Internet

https://peerj.com/articles/4779.pdf

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