Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T Cells

Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T Cells

Thymic selection constitutes the first checkpoint in T-cell development to purge autoreactive T cells. Most of our understanding of this process comes from animal models because of the challenges of studying thymopoiesis and how T cell receptor (TCR) specificity impacts thymocyte phenotype in humans...

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Bibliographic Details
Main Authors: Yang Li, Nato Teteloshvili, Shulian Tan, Samhita Rao, Arnold Han, Yong-Guang Yang, Rémi J. Creusot
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
human thymocyte
thymic selection
clonal deletion
autoreactive
T cell receptor
humanized mouse
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00063/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00063/full

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