Using parental phenotypes in case-parent studies

Using parental phenotypes in case-parent studies

In studies of case-parent triads, information is often collected about history of the condition in the parents, but typically parental phenotypes are ignored. Including that information in analyses may increase power to detect genetic association for autosomal variants. Our proposed approach uses pa...

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Bibliographic Details
Main Authors: Min eShi, David eUmbach, Clarice eWeinberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Genetics
Subjects:
association study
snps
likelihood ratio test
case-parent triad
parental phenotype
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00221/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00221/full

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