Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment

Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment

The tumor suppressor p53 is the most frequently mutated gene in human cancers. Most of the mutations are missense leading to loss of p53 function in inducing apoptosis and senescence. In addition to these autonomous effects of p53 inactivation/dysfunction on tumorigenesis, compelling evidence sugges...

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Bibliographic Details
Main Authors: Yan Cui, Gang Guo
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
tumor suppressor p53
p53 inactivation
tumor microenvironment
immune suppression
inflammation
innate immunity
adaptive antitumor immunity
immunotherapy
Online Access:http://www.mdpi.com/1422-0067/17/11/1942

Internet

http://www.mdpi.com/1422-0067/17/11/1942

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