Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

Cognitive impairment in Down syndrome (DS) involves the hippocampus. In the Ts65Dn mouse model of DS, deficits in hippocampus-dependent learning and synaptic plasticity were linked to enhanced inhibition. However, the mechanistic basis of changes in inhibitory efficiency remains largely unexplored,...

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Bibliographic Details
Main Authors: Alexander M. Kleschevnikov, Pavel V. Belichenko, Jessica Gall, Lizzy George, Rachel Nosheny, Michael T. Maloney, Ahmad Salehi, William C. Mobley
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Neurobiology of Disease
Subjects:
Inhibitory system
GABAA receptor
GABAB receptor
Evoked inhibitory postsynaptic currents
IPSC
Potassium channels
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611100341X

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http://www.sciencedirect.com/science/article/pii/S096999611100341X

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