Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.

Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.

Proline-specific dipeptidyl peptidases (DPPs) are emerging targets for drug development. DPP4 inhibitors are approved in many countries, and other dipeptidyl peptidases are often referred to as DPP4 activity- and/or structure-homologues (DASH). Members of the DASH family have overlapping substrate s...

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Bibliographic Details
Main Authors: Gustavo Arruda Bezerra, Elena Dobrovetsky, Aiping Dong, Almagul Seitova, Lissete Crombett, Lisa M Shewchuk, Annie M Hassell, Sharon M Sweitzer, Thomas D Sweitzer, Patrick J McDevitt, Kyung O Johanson, Karen M Kennedy-Wilson, Doug Cossar, Alexey Bochkarev, Karl Gruber, Sirano Dhe-Paganon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3430648?pdf=render

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http://europepmc.org/articles/PMC3430648?pdf=render

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