Structural Landscape of the Transition from an ssDNA Dumbbell Plus Its Complementary Hairpin to a dsDNA Microcircle Via a Kissing Loop Intermediate

The experimental construction of a double-stranded DNA microcircle of only 42 base pairs entailed a great deal of ingenuity and hard work. However, figuring out the three-dimensional structures of intermediates and the final product can be particularly baffling. Using a combination of model building...

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Bibliographic Details
Main Authors: Alberto Mills, Federico Gago
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
DNA
Online Access:https://www.mdpi.com/1420-3049/26/10/3017