The role of selection in shaping diversity of natural M. tuberculosis populations.

Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), is estimated to infect a new host every second. While analyses of genetic data from natural populations of M.tb have emphasized the role of genetic drift in shaping patterns of diversity, the influence of natural selection on this su...

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Bibliographic Details
Main Authors: Caitlin S Pepperell, Amanda M Casto, Andrew Kitchen, Julie M Granka, Omar E Cornejo, Edward C Holmes, Bruce Birren, James Galagan, Marcus W Feldman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3744410?pdf=render