Fertilization and Cleavage Axes Differ In Primates Conceived By Conventional (IVF) Versus Intracytoplasmic Sperm Injection (ICSI)

Abstract With nearly ten million babies conceived globally, using assisted reproductive technologies, fundamental questions remain; e.g., How do the sperm and egg DNA unite? Does ICSI have consequences that IVF does not? Here, pronuclear and mitotic events in nonhuman primate zygotes leading to the...

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Bibliographic Details
Main Authors: Calvin R. Simerly, Diana Takahashi, Ethan Jacoby, Carlos Castro, Carrie Hartnett, Laura Hewitson, Christopher Navara, Gerald Schatten
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-51815-4