Inhibiting the kynurenine pathway in spinal cord injury: Multiple therapeutic potentials?

Inhibiting the kynurenine pathway in spinal cord injury: Multiple therapeutic potentials?

Chronic induction of the kynurenine pathway (KP) contributes to neuroinflammation by producing the excitotoxin quinolinic acid (QUIN). This has led to significant interest in the development of inhibitors of this pathway, particularly in the context of neurodegenerative disease. However, acute spina...

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Bibliographic Details
Main Authors: Kelly R Jacobs, David B Lovejoy
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
spinal cord injury; neuroinflammation; kynurenine pathway; activated microglia; infiltrating macrophages; quinolinic acid; neuropsychiatry; depression
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2073;epage=2076;aulast=Jacobs

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2073;epage=2076;aulast=Jacobs

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