Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: A post-mortem study in human control subjects

Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: A post-mortem study in human control subjects

Parkinson's disease (PD) is characterized by loss of dopaminergic (DA) neurons in the human midbrain, which varies greatly among mesencephalic subregions. The genetic expression profiles of mesencephalic DA neurons particularly prone to degenerate during PD (nigrosome 1 within the substantia ni...

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Bibliographic Details
Main Authors: Lixia Lu, Frauke Neff, Daniel Alvarez Fischer, Carmen Henze, Etienne C. Hirsch, Wolfgang H. Oertel, Jürgen Schlegel, Andreas Hartmann
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Laser capture microdissection
RAP-PCR
Real time quantitative PCR
Gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000787

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http://www.sciencedirect.com/science/article/pii/S0969996106000787

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