An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats

Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors. In this research, an original analysis method was established for the quantification of osimertinib by ultra-performance liquid chromatography...

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Bibliographic Details
Main Authors: Song-Tao Dong, Ying Li, Hao-Tian Yang, Yin Wu, Ya-Jing Li, Cong-Yang Ding, Lu Meng, Zhan-Jun Dong, Yuan Zhang
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
rat
Online Access:https://www.mdpi.com/1420-3049/23/11/2894