DNA methylome profiling at single-base resolution through bisulfite sequencing of 5mC-immunoprecipitated DNA

DNA methylome profiling at single-base resolution through bisulfite sequencing of 5mC-immunoprecipitated DNA

Abstract Background Detection of DNA methylome at single-base resolution is a significant challenge but promises to shed considerable light on human disease etiology. Current technologies could not detect DNA methylation genome-wide at single-base resolution with small amount of sequencing data and...

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Bibliographic Details
Main Authors: Zhen Jia, Yueyi Shi, Lei Zhang, Yipeng Ren, Tong Wang, Lejun Xing, Baorong Zhang, Guolan Gao, Rongfa Bu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Biotechnology
Subjects:
DNA methylome
MB-seq
MRB-seq
Novel technology
Single-base resolution
Online Access:http://link.springer.com/article/10.1186/s12896-017-0409-7

Internet

http://link.springer.com/article/10.1186/s12896-017-0409-7

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