Gestational Exposure to Sodium Valproate Disrupts Fasciculation of the Mesotelencephalic Dopaminergic Tract, With a Selective Reduction of Dopaminergic Output From the Ventral Tegmental Area

Gestational Exposure to Sodium Valproate Disrupts Fasciculation of the Mesotelencephalic Dopaminergic Tract, With a Selective Reduction of Dopaminergic Output From the Ventral Tegmental Area

Gestational exposure to valproic acid (VPA) is known to cause behavioral deficits of sociability, matching similar alterations in human autism spectrum disorder (ASD). Available data are scarce on the neuromorphological changes in VPA-exposed animals. Here, we focused on alterations of the dopaminer...

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Bibliographic Details
Main Authors: Ágota Ádám, Róbert Kemecsei, Verónica Company, Raquel Murcia-Ramón, Iris Juarez, László I. Gerecsei, Gergely Zachar, Diego Echevarría, Eduardo Puelles, Salvador Martínez, András Csillag
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroanatomy
Subjects:
nigrostriatal pathway
ventral tegmentum
axonal growth
fasciculation
ASD
Online Access:https://www.frontiersin.org/article/10.3389/fnana.2020.00029/full

Internet

https://www.frontiersin.org/article/10.3389/fnana.2020.00029/full

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