TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

Several neurodegenerative diseases are driven by the toxic gain-of-function of specific proteins within the brain. Elevated levels of alpha-synuclein (α-Syn) appear to drive neurotoxicity in Parkinson's disease (PD); neuronal accumulation of tau is a hallmark of Alzheimer's disease (AD); a...

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Bibliographic Details
Main Authors: Maxime WC Rousseaux, Maria de Haro, Cristian A Lasagna-Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar-Nejad, Ismael Al-Ramahi, Ajay Sharma, Lauren See, Nan Lu, Luis Vilanova-Velez, Tiemo J Klisch, Thomas F Westbrook, Juan C Troncoso, Juan Botas, Huda Y Zoghbi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
Parkinson's disease
Alzheimer's disease
neurodegeneration
synucleinopathies
tauopathies
Online Access:https://elifesciences.org/articles/19809

Internet

https://elifesciences.org/articles/19809

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