Discovery of a cooperative mode of inhibiting RIPK1 kinase

Discovery of a cooperative mode of inhibiting RIPK1 kinase

Abstract RIPK1, a death domain-containing kinase, has been recognized as an important therapeutic target for inhibiting apoptosis, necroptosis, and inflammation under pathological conditions. RIPK1 kinase inhibitors have been advanced into clinical studies for the treatment of various human diseases...

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Bibliographic Details
Main Authors: Huyan Meng, Guowei Wu, Xinsuo Zhao, Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu, Ying Li, Lifeng Pan, Xiaoxu Tian, Ping Wu, Chao Peng, Junying Yuan, Guohui Li, Li Tan, Zhaoyin Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00278-x

Internet

https://doi.org/10.1038/s41421-021-00278-x

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