CD21lo/−CD27−IgM− Double-Negative B Cells Accumulate in the Joints of Patients With Antinuclear Antibody-Positive Juvenile Idiopathic Arthritis

CD21lo/−CD27−IgM− Double-Negative B Cells Accumulate in the Joints of Patients With Antinuclear Antibody-Positive Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) encompasses a heterogeneous group of diseases. The appearance of antinuclear antibodies (ANAs) in almost half of the patients suggests B cell dysregulation as a distinct pathomechanism in these patients. Additionally, ANAs were considered potential biomarkers enco...

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Bibliographic Details
Main Authors: Johannes Dirks, Jonas Fischer, Gabriele Haase, Annette Holl-Wieden, Christine Hofmann, Hermann Girschick, Henner Morbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pediatrics
Subjects:
juvenile idiopathic arthritis
B cells
antinuclear antibodies
synovial fluid
double negative B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.635815/full

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https://www.frontiersin.org/articles/10.3389/fped.2021.635815/full

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