Novel in vivo imaging analysis of an inner ear drug delivery system in mice: comparison of inner ear drug concentrations over time after transtympanic and systemic injections.

Novel in vivo imaging analysis of an inner ear drug delivery system in mice: comparison of inner ear drug concentrations over time after transtympanic and systemic injections.

OBJECTIVE: Systemic steroid injections are used to treat idiopathic sudden-onset sensorineural hearing loss (ISSHL) and some inner ear disorders. Recent studies show that transtympanic (TT) steroid injections are effective for treating ISSHL. As in vivo monitoring of drug delivery dynamics for inner...

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Bibliographic Details
Main Authors: Sho Kanzaki, Masato Fujioka, Akimasa Yasuda, Shinsuke Shibata, Masaya Nakamura, Hirotaka James Okano, Kaoru Ogawa, Hideyuki Okano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3520978?pdf=render

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http://europepmc.org/articles/PMC3520978?pdf=render

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