Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non toxic modified pyrrolo[2,3-b]pyrazine derivatives

Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non toxic modified pyrrolo[2,3-b]pyrazine derivatives

Cystic Fibrosis is a major inherited disorder involving abnormalities of fluid and electrolyte transport in a number of different organs due to abnormal function of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein. We recently identified a family of CFTR activators, which contains...

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Bibliographic Details
Main Authors: Luc eDannhoffer, Arnaud eBillet, Mathilde eJollivet, Patricia eMelin-Heschel, Christelle eFaveau, Frederic eBecq
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-08-01
Series:Frontiers in Pharmacology
Subjects:
Cystic Fibrosis
Epithelial Cells
Ion Transport
CFTR
activator and inhibitor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00048/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00048/full

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