CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

CCN1 (CYR61) stimulates active angiogenesis in various tumours, although the mechanism is largely unknown. Here, we report that CCN1 is a key regulator of endothelial tip cell activity in angiogenesis. Microvessel networks and directional vascular cell migration patterns were deformed in ccn1-knockd...

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Bibliographic Details
Main Authors: Myo-Hyeon Park, Ae kyung Kim, Sarala Manandhar, Su-Young Oh, Gun-Hyuk Jang, Li Kang, Dong-Won Lee, Do Young Hyeon, Sun-Hee Lee, Hye Eun Lee, Tae-Lin Huh, Sang Heon Suh, Daehee Hwang, Kyunghee Byun, Hae-Chul Park, You Mie Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
Cyr61
integrinαvβ3
VEGFR2
YAP/TAZ
Online Access:https://elifesciences.org/articles/46012

Internet

https://elifesciences.org/articles/46012

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