Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Abstract Background Ulcerative colitis is a type of chronic inflammatory bowel disease closely associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley leaf (BL) has a long history of use in Traditional Chinese Medicine with potential health-promoting effects on inte...

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Bibliographic Details
Main Authors: Daotong Li, Yu Feng, Meiling Tian, Junfu Ji, Xiaosong Hu, Fang Chen
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Microbiome
Subjects:
Barley leaf
Colitis
Gut microbiota
Purine metabolite
Mucosal barrier
PPARγ
Online Access:https://doi.org/10.1186/s40168-021-01028-7

Internet

https://doi.org/10.1186/s40168-021-01028-7

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