Increased Brain-Derived Neurotrophic Factor in Lumbar Dorsal Root Ganglia Contributes to the Enhanced Exercise Pressor Reflex in Heart Failure

Increased Brain-Derived Neurotrophic Factor in Lumbar Dorsal Root Ganglia Contributes to the Enhanced Exercise Pressor Reflex in Heart Failure

An exaggerated exercise pressor reflex (EPR) is associated with excessive sympatho-excitation and exercise intolerance in the chronic heart failure (CHF) state. We hypothesized that brain-derived neurotrophic factor (BDNF) causes the exaggerated EPR via sensitizing muscle mechanosensitive afferents...

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Bibliographic Details
Main Authors: Alicia M. Schiller, Juan Hong, Zhiqiu Xia, Han-Jun Wang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
exercise
mechanoreflex
cardiovascular reflexes
neurotrophic factors
Online Access:https://www.mdpi.com/1422-0067/20/6/1480

Internet

https://www.mdpi.com/1422-0067/20/6/1480

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