Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo

Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo

Background: Tamoxifen is used to treat breast cancer and cancer recurrences. After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human. These active compounds are inactivated by the same UDP-glucuronosy...

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Bibliographic Details
Main Authors: Florian Gabel, Anne-Sophie Aubry, Volodya Hovhannisyan, Virginie Chavant, Ivan Weinsanto, Tando Maduna, Pascal Darbon, Yannick Goumon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
Tamoxifen
4OH-tamoxifen
endoxifen
Morphine
metabolism
CYP
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00025/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00025/full

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