Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia.

Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia.

The development of thrombocytopenia in sepsis is a poor prognostic indicator associated with a significantly increased mortality risk. Mechanisms underlying this phenomenon remain to be clearly elucidated. Matrix metalloproteinases (MMPs) are enzymes that regulate the turnover of the extra-cellular...

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Bibliographic Details
Main Authors: Caroline M Larkin, Nadhim Kamil Hante, Eamon P Breen, Krzysztof A Tomaszewski, Simon Eisele, Marek W Radomski, Thomas A Ryan, Maria-Jose Santos-Martinez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5937753?pdf=render

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http://europepmc.org/articles/PMC5937753?pdf=render

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