Recombinant γY278H Fibrinogen Showed Normal Secretion from CHO Cells, but a Corresponding Heterozygous Patient Showed Hypofibrinogenemia

Recombinant γY278H Fibrinogen Showed Normal Secretion from CHO Cells, but a Corresponding Heterozygous Patient Showed Hypofibrinogenemia

We identified a novel heterozygous hypofibrinogenemia, γY278H (Hiroshima). To demonstrate the cause of reduced plasma fibrinogen levels (functional level: 1.12 g/L and antigenic level: 1.16 g/L), we established γY278H fibrinogen-producing Chinese hamster ovary (CHO) cells. An enzyme-linked immunosor...

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Bibliographic Details
Main Authors: Tomu Kamijo, Takahiro Kaido, Masahiro Yoda, Shinpei Arai, Kazuyoshi Yamauchi, Nobuo Okumura
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
congenital fibrinogen disorders
hypofibrinogenemia
Chinese hamster ovary cells
recombinant fibrinogen
plasmin degradation
Online Access:https://www.mdpi.com/1422-0067/22/10/5218

Internet

https://www.mdpi.com/1422-0067/22/10/5218

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