Mincle and STING-Stimulating Adjuvants Elicit Robust Cellular Immunity and Drive Long-Lasting Memory Responses in a Foot-and-Mouth Disease Vaccine

Mincle and STING-Stimulating Adjuvants Elicit Robust Cellular Immunity and Drive Long-Lasting Memory Responses in a Foot-and-Mouth Disease Vaccine

Conventional foot-and-mouth disease (FMD) vaccines exhibit several limitations, such as the slow induction of antibodies, short-term persistence of antibody titers, as well as low vaccine efficacy and safety, in pigs. Despite the importance of cellular immune response in host defense at the early st...

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Bibliographic Details
Main Authors: Min Ja Lee, Hyundong Jo, Sung Ho Shin, Su-Mi Kim, Byounghan Kim, Hang Sub Shim, Jong-Hyeon Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
PRR ligands
cytokines
adjuvants
foot-and-mouth disease
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02509/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02509/full

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