Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin

Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin

Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to play a role in cancer progression, alter apo...

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Bibliographic Details
Main Authors: Jia Wang, Ruwen Cui, Cecila G. Clement, Ranjana Nawgiri, Don W. Powell, Irina V. Pinchuk, Tammara L. Watts
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
PDGFR-α
AKT
oral cancer
crenolanib
apoptosis
mesenchymal stem cells
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00552/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00552/full

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