Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.

Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.

Alzheimer's disease (AD) is characterized by progressive cognitive decline associated with a featured neuropathology (neuritic plaques and neurofibrillary tangles). Several studies have implicated oxidative damage to DNA, DNA repair, and altered cell-cycle regulation in addition to cell death i...

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Bibliographic Details
Main Authors: Aderbal R T Silva, Ana Cecília Feio Santos, Jose M Farfel, Lea T Grinberg, Renata E L Ferretti, Antonio Hugo Jose Froes Marques Campos, Isabela Werneck Cunha, Maria Dirlei Begnami, Rafael M Rocha, Dirce M Carraro, Carlos Alberto de Bragança Pereira, Wilson Jacob-Filho, Helena Brentani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4061071?pdf=render

Internet

http://europepmc.org/articles/PMC4061071?pdf=render

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