Metformin Attenuates Bone Cancer Pain by Reducing TRPV1 and ASIC3 Expression

Metformin Attenuates Bone Cancer Pain by Reducing TRPV1 and ASIC3 Expression

Bone cancer pain (BCP) is a common pathologic pain associated with destruction of bone and pathological reconstruction of nervous system. Current treatment strategies in clinical is inadequate and have unacceptable side effects due to the unclear pathology mechanism. In the present study, we showed...

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Bibliographic Details
Main Authors: He-Ya Qian, Fang Zhou, Rui Wu, Xiao-Jun Cao, Tao Zhu, Hao-Dong Yuan, Ya-Nan Chen, Ping-An Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
metformin
bone cancer pain
ASIC3
TRPV1
dorsal root ganglions
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.713944/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.713944/full

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