UBC13 is an RNF213‐associated E2 ubiquitin‐conjugating enzyme, and Lysine 63‐linked ubiquitination by the RNF213‐UBC13 axis is responsible for angiogenic activity

UBC13 is an RNF213‐associated E2 ubiquitin‐conjugating enzyme, and Lysine 63‐linked ubiquitination by the RNF213‐UBC13 axis is responsible for angiogenic activity

Abstract Moyamoya disease (MMD) is a cryptogenic vascular disorder in the intracranial arteries. RING protein 213 (RNF213) is the susceptibility gene for MMD, and encodes a RING domain and a Walker motif. Herein, we identified UBC13 (UBE2N) as an E2 ubiquitin‐conjugating enzyme for RNF213 E3 ubiquit...

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Bibliographic Details
Main Authors: Toshiyuki Habu, Kouji H. Harada
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:FASEB BioAdvances
Subjects:
angiogenic activity
lysine‐linked ubiquitination
Moyamoya disease
RNF213
Online Access:https://doi.org/10.1096/fba.2019-00092

Internet

https://doi.org/10.1096/fba.2019-00092

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