Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia

Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia

Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects i...

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Bibliographic Details
Main Authors: Hannes Schmid, Corina Schneidawind, Simona Jahnke, Felix Kettemann, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Lothar Kanz, Paul B. Savage, Dominik Schneidawind
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
cytotherapy
graft-versus-host disease
graft-versus-leukemia
hematopoietic cell transplantation
invariant natural killer T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01817/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01817/full

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