Intronic Alternative Polyadenylation in the Middle of the <i>DMD</i> Gene Produces Half-Size N-Terminal Dystrophin with a Potential Implication of ECG Abnormalities of DMD Patients

Intronic Alternative Polyadenylation in the Middle of the <i>DMD</i> Gene Produces Half-Size N-Terminal Dystrophin with a Potential Implication of ECG Abnormalities of DMD Patients

The <i>DMD</i> gene is one of the largest human genes, being composed of 79 exons, and encodes dystrophin Dp427m which is deficient in Duchenne muscular dystrophy (DMD). In some DMD patient, however, small size dystrophin reacting with antibody to N-terminal but not to C-terminal has bee...

Full description

Bibliographic Details
Main Authors: Abdul Qawee Mahyoob Rani, Tetsushi Yamamoto, Tatsuya Kawaguchi, Kazuhiro Maeta, Hiroyuki Awano, Hisahide Nishio, Masafumi Matsuo
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
<i>DMD</i>
intronic alternative polyadenylation
dystrophin
Dpm234
Duchenne muscular dystrophy
iPS-derived cardiomyocytes
Online Access:https://www.mdpi.com/1422-0067/21/10/3555

Internet

https://www.mdpi.com/1422-0067/21/10/3555

Similar Items