Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury

Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury

Cathepsin D is one of the major lysosomal aspartic proteases that is essential for the normal functioning of the autophagy-lysosomal system. In the kidney, cathepsin D is enriched in renal proximal tubular epithelial cells, and its levels increase during acute kidney injury. To investigate how cathe...

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Bibliographic Details
Main Authors: Chigure Suzuki, Isei Tanida, Masaki Ohmuraya, Juan Alejandro Oliva Trejo, Soichiro Kakuta, Takehiko Sunabori, Yasuo Uchiyama
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
cathepsin D
renal proximal tubular cells
ischemia/reperfusion injury
gene knockout mouse
Online Access:https://www.mdpi.com/1422-0067/20/7/1711

Internet

https://www.mdpi.com/1422-0067/20/7/1711

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