Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

Objective: Exploitation of protective metabolic pathways within injured myocardium still remains an unclarified therapeutic target in heart disease. Moreover, while the roles of altered fatty acid and glucose metabolism in the failing heart have been explored, the influence of highly dynamic and nu...

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Bibliographic Details
Main Authors: Rebecca C. Schugar, Ashley R. Moll, D. André d’Avignon, Carla J. Weinheimer, Attila Kovacs, Peter A. Crawford
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Molecular Metabolism
Subjects:
Myocardial ketone body metabolism
Nuclear magnetic resonance (NMR) measurement of substrate metabolism
Ventricular remodeling
Oxidative stress
Mitochondrial metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877814001367

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http://www.sciencedirect.com/science/article/pii/S2212877814001367

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