MiRNAs Targeting Double Strand DNA Repair Pathways Lurk in Genomically Unstable Rare Fragile Sites and Determine Cancer Outcomes

MiRNAs Targeting Double Strand DNA Repair Pathways Lurk in Genomically Unstable Rare Fragile Sites and Determine Cancer Outcomes

Double strand break (DSB) repair mechanisms guard genome integrity and their deterioration causes genomic instability. Common and rare fragile sites (CFS and RFS, respectively) are particularly vulnerable to instability, and there is an inverse correlation between fragile site (FS) expression and DS...

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Bibliographic Details
Main Authors: Stephan Marquardt, Christin Richter, Brigitte M. Pützer, Stella Logotheti
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
rare fragile sites
FRAXA
cancer
miRNA
non-homologous end-joining
homologous recombination
Online Access:https://www.mdpi.com/2072-6694/12/4/876

Internet

https://www.mdpi.com/2072-6694/12/4/876

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