Proteomic fingerprints of damage in extracellular matrix assemblies

In contrast to the dynamic intracellular environment, structural extracellular matrix (ECM) proteins with half-lives measured in decades, are susceptible to accumulating damage. Whilst conventional approaches such as histology, immunohistochemistry and mass spectrometry are able to identify age- and...

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Bibliographic Details
Main Authors: Alexander Eckersley, Matiss Ozols, Ronan O'Cualain, Emma-Jayne Keevill, April Foster, Suzanne Pilkington, David Knight, Christopher E.M. Griffiths, Rachel E.B. Watson, Michael J. Sherratt
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Matrix Biology Plus
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028520300089