Enhanced Antitumor Effects of Adenoviral-Mediated siRNA against GRP78 Gene on Adenosine-Induced Apoptosis in Human Hepatoma HepG2 Cells

Enhanced Antitumor Effects of Adenoviral-Mediated siRNA against GRP78 Gene on Adenosine-Induced Apoptosis in Human Hepatoma HepG2 Cells

Our previous studies show that adenosine-induced apoptosis is involved in endoplasmic reticulum stress in HepG2 cells. In this study, we have investigated whether knockdown of GRP78 by short hairpin RNA (shRNA) increases the cytotoxic effects of adenosine in HepG2 cells. The adenovirus vector-delive...

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Bibliographic Details
Main Authors: Ling-Fei Wu, Yi-Tian Guo, Qing-Hua Zhang, Meng-Qi Xiang, Wei Deng, Yan-Qing Ye, Ze-Jin Pu, Jia-Lin Feng, Guan-You Huang
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
ER stress
glucose-regulated protein 78 (GRP78)
adenosine
RNA interference
caspase-4
Online Access:http://www.mdpi.com/1422-0067/15/1/525

Internet

http://www.mdpi.com/1422-0067/15/1/525

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