The nitric oxide donor JS-K sensitizes U87 glioma cells to repetitive irradiation

As a potent radiosensitizer nitric oxide (NO) may be a putative adjuvant in the treatment of malignant gliomas which are known for their radio- and chemoresistance. The NO donor prodrug JS-K (O2-(2.4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen-1-ium-1,2-diolate) allows cell-type spec...

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Bibliographic Details
Main Authors: Max Heckler, Nadja Osterberg, Jessica Guenzle, Nina Kristin Thiede-Stan, Wilfried Reichardt, Claudia Weidensteiner, Joseph E Saavedra, Astrid Weyerbrock
Format: Article
Language:English
Published: IOS Press 2017-06-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317703922