Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice

Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice

Abstract Several of the identified genetic factors in Amyotrophic Lateral Sclerosis (ALS) point to dysfunction in RNA processing as a major pathogenic mechanism. However, whether a precise RNA pathway is particularly affected remains unknown. Evidence suggests that FUS, that is mutated in familial A...

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Bibliographic Details
Main Authors: Alessia Mirra, Simona Rossi, Silvia Scaricamazza, Michela Di Salvio, Illari Salvatori, Cristiana Valle, Paola Rusmini, Angelo Poletti, Gianluca Cestra, Maria Teresa Carrì, Mauro Cozzolino
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02195-0

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https://doi.org/10.1038/s41598-017-02195-0

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