Ubiquitin carboxyl terminal hydrolyase L1-suppressed autophagic degradation of p21WAF1/Cip1 as a novel feedback mechanism in the control of cardiac fibroblast proliferation.

Ubiquitin carboxyl terminal hydrolyase L1-suppressed autophagic degradation of p21WAF1/Cip1 as a novel feedback mechanism in the control of cardiac fibroblast proliferation.

AIMS:Deubiquitinating enzymes (DUBs) appear to be critical regulators of a multitude of processes such as proliferation, apoptosis, differentiation, and inflammation; however, the potential roles of DUBs in the heart remain to be determined. This study was aimed to explore the role of a DUB, ubiquit...

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Bibliographic Details
Main Authors: Xiaoming Zhang, Linlin Guo, Ting Niu, Lei Shao, Huanjie Li, Weiwei Wu, Wenjuan Wang, Linmao Lv, Qingyun Qin, Fang Wang, Dongqi Tang, Xing Li Wang, Taixing Cui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3986084?pdf=render

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http://europepmc.org/articles/PMC3986084?pdf=render

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