Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

Intensive insulin therapy can prevent or slow the progression of long-term diabetes complications but, at the same time, it increases the risk for episodes of severe hypoglycemia. In our study, we used a protocol intended to mimic the levels of blood glucose that occur in type 1 diabetic patients un...

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Bibliographic Details
Main Authors: Susana Cardoso, Renato X. Santos, Sónia C. Correia, Cristina Carvalho, Maria S. Santos, Inês Baldeiras, Catarina R. Oliveira, Paula I. Moreira
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
Cortex
Hippocampus
Long-term hyperglycemia
Mitochondria
Neurodegeneration
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002951

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http://www.sciencedirect.com/science/article/pii/S0969996112002951

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