A Computer-Based Methodology to Design Non-Standard Peptides Potentially Able to Prevent HOX-PBX1-Associated Cancer Diseases

In the last decades, HOX proteins have been extensively studied due to their pivotal role in transcriptional events. HOX proteins execute their activity by exploiting a cooperative binding to PBX proteins and DNA. Therefore, an increase or decrease in HOX activity has been associated with both solid...

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Bibliographic Details
Main Authors: Maria Rita Gulotta, Giada De Simone, Justin John, Ugo Perricone, Andrea Brancale
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
HOX
PBX
Online Access:https://www.mdpi.com/1422-0067/22/11/5670