Compound K Inhibits Autophagy-Mediated Apoptosis Through Activation of the PI3K-Akt Signaling Pathway Thus Protecting Against Ischemia/Reperfusion Injury

Compound K Inhibits Autophagy-Mediated Apoptosis Through Activation of the PI3K-Akt Signaling Pathway Thus Protecting Against Ischemia/Reperfusion Injury

Background/Aims: A series of reports revealed that autophagy and apoptosis exerted detrimental effects on the pathology of cardiac ischemia/reperfusion (I/R) injury. Ginsenoside compound K (CK), a major intestinal metabolite underlying the pharmacological actions of orally administered ginseng, has...

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Bibliographic Details
Main Authors: Xiangyan Li, Qingxia Huang, Manying Wang, Xiuci Yan, Xinying Song, Rui Ma, Rui Jiang, Daqing Zhao, Liwei Sun
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Compound K
Autophagy
Apoptosis
Ischemic/reperfusion injury
PI3K-Akt pathway
Online Access:https://www.karger.com/Article/FullText/491655

Internet

https://www.karger.com/Article/FullText/491655

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