NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression

NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression

Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a process in which they are embedded in an osteoid. We previously showed that nutrient restriction promotes the osteocyte transcriptional program and is associated with increased mitochondrial biogenesis. Here, we sho...

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Bibliographic Details
Main Authors: Cristina Sánchez-de-Diego, Leonardo Pedrazza, Carolina Pimenta-Lopes, Arturo Martinez-Martinez, Norma Dahdah, José Antonio Valer, Pablo Garcia-Roves, Jose Luis Rosa, Francesc Ventura
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Redox Biology
Subjects:
Bone
Osteocyte
NRF2
Oxidative stress
Osteoporosis
Bone homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310508

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http://www.sciencedirect.com/science/article/pii/S2213231720310508

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