Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse

We previously identified Wiz in a mouse screen for epigenetic modifiers. Due to its known association with G9a/GLP, Wiz is generally considered a transcriptional repressor. Here, we provide evidence that it may also function as a transcriptional activator. Wiz levels are high in the brain, but its f...

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Bibliographic Details
Main Authors: Luke Isbel, Lexie Prokopuk, Haoyu Wu, Lucia Daxinger, Harald Oey, Alex Spurling, Adam J Lawther, Matthew W Hale, Emma Whitelaw
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/15082