Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1)

Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1)

Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by i...

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Bibliographic Details
Main Authors: Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi
Format: Article
Language:English
Published: Korea Genome Organization 2016-06-01
Series:Genomics & Informatics
Subjects:
apical membrane antigen 1
drug design
hydrophobic interaction
molecular docking analyses
rhoptry neck protein 2
toxoplasmosis
Online Access:http://genominfo.org/upload/pdf/gni-14-53.pdf

Internet

http://genominfo.org/upload/pdf/gni-14-53.pdf

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