Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

Abstract Inter-individual differences in cortisol production by the hypothalamus–pituitary–adrenal (HPA) axis are thought to contribute to clinical and pathological heterogeneity of multiple sclerosis (MS). At the same time, accumulating evidence indicates that MS pathogenesis may originate in the n...

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Bibliographic Details
Main Authors: Jeroen Melief, Marie Orre, Koen Bossers, Corbert G. van Eden, Karianne G. Schuurman, Matthew R. J. Mason, Joost Verhaagen, Jörg Hamann, Inge Huitinga
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis
Normal-appearing white matter
HPA axis
Transcriptome
Online Access:http://link.springer.com/article/10.1186/s40478-019-0705-7

Internet

http://link.springer.com/article/10.1186/s40478-019-0705-7

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