Effect of an alkyl spacer on the morphology and internalization of MUC1 aptamer‐naphthalimide amphiphiles for targeting and imaging triple negative breast cancer cells

Effect of an alkyl spacer on the morphology and internalization of MUC1 aptamer‐naphthalimide amphiphiles for targeting and imaging triple negative breast cancer cells

Abstract Despite decades of research, there are few targeted treatment options available for triple negative breast cancer (TNBC), leaving chemotherapy, and radiation treatment regimes with poor response and high toxicity. Herein aptamer‐amphiphiles were synthesized which selectively bind to the muc...

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Bibliographic Details
Main Authors: Huihui Kuang, Zachary Schneiderman, Ahmed M. Shabana, Gabriella C. Russo, Jun Guo, Denis Wirtz, Efrosini Kokkoli
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Bioengineering & Translational Medicine
Subjects:
aptamer nanofibers
effect of spacer on self‐assembly
nanoparticles
ssDNA aptamer‐amphiphiles
targeted drug delivery
targeting MUC1
Online Access:https://doi.org/10.1002/btm2.10194

Internet

https://doi.org/10.1002/btm2.10194

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