Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer’s disease (AD). The production and deposition of Aβ are important factors affecting AD progression and prognosis. The deposition of neurotoxic Aβ contributes to damage of the blood–brain barrier. However, the BBB is also crucial in ma...

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Bibliographic Details
Main Authors: Dong Wang, Fanglian Chen, Zhaoli Han, Zhenyu Yin, Xintong Ge, Ping Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyloid-β
blood–brain barrier
Alzheimer’s disease
low-density lipoprotein receptor-related protein 1
receptor for advanced glycation end products
P-glycoprotein
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.695479/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.695479/full

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