Enzymatically polymerised polyphenols prepared from various precursors potentiate antigen-specific immune responses in both mucosal and systemic compartments in mice.

Despite significant modern medicine progress, having an infectious disease is a major risk factor for humans. Mucosal vaccination is now widely considered as the most promising strategy to defeat infectious diseases; however, only live-attenuated and inactivated mucosal vaccines are used in the clin...

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Bibliographic Details
Main Authors: Rui Tada, Miki Ogasawara, Daisuke Yamanaka, Yasuhiro Sakurai, Yoichi Negishi, Hiroshi Kiyono, Naohito Ohno, Jun Kunisawa, Yukihiko Aramaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0246422